PReS-FINAL-2181: Recombinant il-1ra restores the il-18-nk cell axis in steroid naive systemic juvenile idiopathic arthritis
نویسندگان
چکیده
Introduction Systemic onset juvenile idiopathic arthritis (sJIA) is an acquired auto-inflammatory disease characterized by systemic inflammation and innate immune activation reflected in uncontrolled production of cytokines such as IL-1, IL-6 and IL-18. In sJIA, NK cell function is severely hampered despite high levels of IL-18. We recently found that defective phosphorylation of the IL-18 receptor beta is responsible for the deficient IL-18-NK cell axis in sJIA.
منابع مشابه
Akinra restores the defective IL-18 NK cell axis in steroid naïve systemic onset JIA patients
Systemic Onset Juvenile Idiopathic Arthritis (SoJIA) is characterized by systemic inflammation and chronic arthritis. Intriguingly, the IL-18-NK cell axis seems to be disturbed in the majority of SoJIA patients. The observed NK cell dysfunction in SoJIA patients contributes to important features of the disease including the susceptibility for macrophage activation syndrome. Here we describe the...
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Introduction Systemic onset Juvenile Idiopathic Artritis (sJIA) is considered to be an autoinflammatory disease. The S100-proteins S100A8, S100A9 and S100A12 in serum and interleukin (IL)-18 in plasma are extremely elevated in sJIA patients and have been proposed to be useful biomarkers for diagnosis, disease activity and response to therapy. Moreover, sJIA patients seem to have a defective IL-...
متن کامل4.5 Defective phosphorylation of the interleukin 18 receptor beta-chain causes impaired NK cell function in systemic onset Juvenile Idiopathic Arthritis
Systemic onset Juvenile Idiopathic Arthritis (SoJIA) is an autoimmune disease characterised by arthritis and systemic features. Cytokines like IL1, IL6 and IL18 are thought to be responsible for clinical symptoms. IL18 can drive NK cell function. Recently we showed high IL18 levels in plasma correlate with disease activity in SoJIA [1]. Since SoJIA patients have diminished NK cell function we i...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013